Scientists from Russia and Italy studied a new axis of the pathway that prevents the development of liver fibrosis. The role of GILZ protein in curbing the disease progression was shown in a study using mice models and confirmed by clinical data.
University of South Australia researchers have identified an enzyme that may help to curb chronic kidney disease, which affects approximately 700 million people worldwide.
May 5, 2021 11:00am MIT biologists reported that the cell elimination process called cell extrusion could offer new insights into stopping cancer. (Vivek Dwivedi)
Cancer cells multiply out of control because they re able to escape a mechanism known as programed cell death. But scientists at the Massachusetts Institute of Technology (MIT) and King’s College London have uncovered key functions of another pathway with a long evolutionary history that the body uses to dispose of those rogue cells.
During this process, called cell extrusion, cells are squeezed out of the lining of tissues. The team, led by Nobel laureate H. Robert Horvitz, Ph.D., found that the process is triggered when cells fail to replicate their DNA during cell division, according to a study published in Nature.
E-Mail
Scientists from Russia and Italy studied a new axis of the pathway that prevents the development of liver fibrosis. The role of GILZ protein in curbing the disease progression was shown in a study using mice models and confirmed by clinical data. These findings can be used in the treatment of liver fibrosis in humans. The research was published in the journal
Cell Death & Disease.
Fibrosis combines an overgrowth of connective tissue and a decline in the liver function that can be caused by a viral infection, alcohol intoxication, autoimmune diseases or other liver disorders. If left untreated, fibrosis can lead to cirrhosis and even death. Inflammatory processes ? complex cascades of molecular interactions between the cells of the immune system ? play an important role in the progression of fibrosis, therefore, its treatment requires thorough understanding of those processes at the molecular level. The most common anti-inflammatory agents, such as glucocorticoids, are w
Date Time
Enzyme that could help 700 million people worldwide
University of South Australia researchers have identified an enzyme that may help to curb chronic kidney disease, which affects approximately 700 million people worldwide.
This enzyme, NEDD4-2, is critical for kidney health, says UniSA Centre for Cancer Biology scientist Dr Jantina Manning in a new paper published this month in Cell Death & Disease.
The early career researcher and her colleagues, including 2020 SA Scientist of the Year Professor Sharad Kumar, have shown in an animal study the correlation between a high salt diet, low levels of NEDD4-2 and advanced kidney disease.