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Mouse Model of Alzheimer s Reveals Some Plaques May Defend and Not Destroy

Mouse Model of Alzheimer s Reveals Some Plaques May Defend and Not Destroy
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Youtong huangGreg lemkeSalk molecular neurobiology laboratoryMolecular neurobiologyகிரெக் லெம்கீசாள்க் மூலக்கூறு நரம்பியல் ஆய்வகம்மூலக்கூறு நரம்பியல்

In surprising twist, some Alzheimer s plaques may be protective, not destructive

E-Mail IMAGE: A dense-core amyloid-beta plaque (red) surrounded by microglia that lack TAM receptors (white) in the brain of a mouse with Alzheimer s disease view more Credit: Salk Institute LA JOLLA (April 15, 2021) One of the characteristic hallmarks of Alzheimer s disease (AD) is the buildup of amyloid-beta plaques in the brain. Most therapies designed to treat AD target these plaques, but they ve largely failed in clinical trials. New research by Salk scientists upends conventional views of the origin of one prevalent type of plaque, indicating a reason why treatments have been unsuccessful. The traditional view holds that the brain s trash-clearing immune cells, called microglia, inhibit the growth of plaques by eating them. The Salk scientists show instead that microglia promote the formation of dense-core plaques, and that this action sweeps wispy plaque material away from neurons, where it causes cell death. The research, which was published in

United statesKaisae happonenMarguerite vogtCarolyn oconnorAxel nimmerjahnPatrickg burrolaYoutong huangGreg lemkeDiego goeddelAmerica foundationCure alzheimer fundHarryb helmsley charitableSalk molecular neurobiology laboratoryCoins for alzheimer researchUs national institutes of healthMaryk chapman charitable

Study sheds new light on reflexive behaviors

Study sheds new light on reflexive behaviors When you touch a hot stove, your hand reflexively pulls away; if you miss a rung on a ladder, you instinctively catch yourself. Both motions take a fraction of a second and require no forethought. Now, researchers at the Salk Institute have mapped the physical organization of cells in the spinal cord that help mediate these and similar critical sensorimotor reflexes. The new blueprint of this aspect of the sensorimotor system, described online in Neuron on November 11, 2020, could lead to a better understanding of how it develops and can go awry in conditions such as chronic itch or pain.

Graziana gattoJoannaj mitchellMartyn gouldingEmily hendersonSalk instituteSalk molecular neurobiology laboratoryProfessor in molecular neurobiology laboratoryRebecca seal of the university pittsburghMolecular neurobiology laboratoryRebecca sealமார்டின் கூல்டிஂக்எமிலி ஹென்டர்சன்சாள்க் நிறுவனம்சாள்க் மூலக்கூறு நரம்பியல் ஆய்வகம்ப்ரொஃபெஸர் இல் மூலக்கூறு நரம்பியல் ஆய்வகம்ரிபேக்க முத்திரை ஆஃப் தி பல்கலைக்கழகம் பிட்ஸ்பர்க்

When it comes to feeling pain, touch or an itch, location matters

Credit: (L) Yolanda Leenders-Goulding; (R) Salk Institute. LA JOLLA (December 10, 2020) When you touch a hot stove, your hand reflexively pulls away; if you miss a rung on a ladder, you instinctively catch yourself. Both motions take a fraction of a second and require no forethought. Now, researchers at the Salk Institute have mapped the physical organization of cells in the spinal cord that help mediate these and similar critical sensorimotor reflexes. The new blueprint of this aspect of the sensorimotor system, described online in Neuron on November 11, 2020, could lead to a better understanding of how it develops and can go awry in conditions such as chronic itch or pain.

Graziana gattoJoannaj mitchellPeter fentonXiangyu renMartyn gouldingPriyabrata halderDavid scaife foundationSalk instituteSalk molecular neurobiology laboratoryRebecca seal of the university pittsburghNational institutes of healthMaryk chapman charitableMolecular neurobiology laboratoryRebecca sealSteeve bouraneStefania di constanzo