Causal ordering among risk factors in the PURE study
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CVD Deaths Increased, Imaging Decreased During Pandemic
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Dec 23, 2020
Participants without cardiovascular disease but who were at increased risk were randomly assigned to receive a polypill (i.e. 1 statin with 3 blood pressure-lowering drugs) or placebo and to receive aspirin or placebo. With 4.6 years follow-up, the incidence of cardiovascular events was lower among participants receiving both the polypill and aspirin than among those receiving both placebos.
Physician’s Weekly interviews the lead study investigator, Prof. Salim Yusuf (Population Health Research Institute, Hamilton, Canada) who presented the results of the TIPS-3 trial at the American Heart Association Scientific Sessions 2020 [1].
TIPS-3 randomised 5,713 people, mostly of South Asian ancestry, who did not have cardiovascular disease but were classified as being at intermediate or high risk as measured by the INTERHEART Risk Score. The polypill contains 40 milligrams of simvastatin, 100 milligrams of atenolol, 25 milligrams of hydrochlorothiazide, and 10 milligram