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Algorithm Bests Clinicians in Predicting Alzheimer s

27 May 2021 Plasma phospho-tau 181 and p-tau 217 can distinguish people with Alzheimer’s disease from controls most, but not all, of the time. To increase diagnostic accuracy, researchers are creating algorithms combining p-tau with other fluid biomarker and diagnostic data. In the May 24 Nature Medicine, researchers led by Oskar Hansson and Sebastian Palmqvist, both at Lund University, Sweden, reported just such an algorithm to predict AD. They report that among people with a subjective memory complaint, plasma p-tau, APOE genotype, executive function, and memory scores together predicted AD onset within two to six years with 90 percent accuracy. In the same cohort, clinicians were about 72 percent accurate. Alzforum first reported on the algorithm at this year’s International Conference on Alzheimer’s and Parkinson’s Diseases (Apr 2021 conference news). 

Investegate |Prothena Corporation plc Announcements | Prothena Corporation plc: Prothena Reports First Quarter 2021 Financial Results and Provides Updated Financial Guidance and R&D Update

VITAL study 9-month results expected to be presented at a medical conference in 2021 Prasinezumab Results from Part 2 of the PASADENA study expected to be presented at an upcoming medical conference PRX004 PRX005 IND expected by 3Q 2021 $80 million potential payment from Bristol Myers Squibb upon exercising their US license option in 2021 PRX012, a potential treatment for Alzheimer’s disease, is a high affinity monoclonal antibody targeting a key epitope within the N-terminus of Aβ IND expected by 1Q 2022 Upcoming Investor Conferences Members of the senior management team will present and participate in investor meetings at the following upcoming investor conferences: BofA Securities 2021 Virtual Health Care Conference, May 13, 2021, at 8:45 AM ET

Prothena Corporation plc: Prothena Reports First Quarter 2021 Financial Results and Provides Updated Financial Guidance and R&D Update

Prothena Corporation plc: Prothena Reports First Quarter 2021 Financial Results and Provides Updated Financial Guidance and R&D Update VITAL study 9-month results expected to be presented at a medical conference in 2021 Prasinezumab Results from Part 2 of the PASADENA study expected to be presented at an upcoming medical conference PRX004 PRX005 IND expected by 3Q 2021 $80 million potential payment from Bristol Myers Squibb upon exercising their US license option in 2021 PRX012, a potential treatment for Alzheimer s disease, is a high affinity monoclonal antibody targeting a key epitope within the N-terminus of Aß IND expected by 1Q 2022 Upcoming Investor Conferences Members of the senior management team will present and participate in investor meetings at the following upcoming investor conferences:

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