COVID-19 Host Genome SV Consortium Identifies Structural Variants with Possible Roles in Pathogenesis and Outcomes in Severely Ill COVID-19 Patients Using Bionano’s Saphyr® System First publication from international consortium highlights prowess of Saphyr in identifying large SVs with clinical significance and in COVID-19, an area with great public health implications
January 11, 2021 08:00 ET | Source: Bionano Genomics Bionano Genomics San Diego, California, UNITED STATES
SAN DIEGO, Jan. 11, 2021 (GLOBE NEWSWIRE) Bionano Genomics, Inc. (Nasdaq: BNGO), announced today the first publication from the COVID-19 Host Genome Structural Variant Consortium. The study found that optical genome mapping (OGM) with Bionano’s Saphyr System identified structural variants (SVs) that affect genes in pathways that control immune and inflammatory response, viral reproduction and mucosal function. The authors believe these S
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Philip Smith, powerhouse Broadway executive, dies at 89 of COVID Tim Balk
Philip Smith, the beloved Brooklyn-born theater enthusiast who climbed from movie usher to the chair of the Shubert Organization, the largest Broadway theater company, died Friday at a Manhattan hospital. He was 89.
The cause of Smith’s death at NewYork-Presbyterian/Columbia University Medical Center was complications of COVID-19, said Bill Evans, a spokesperson for Shubert.
Smith, a burly Broadway powerhouse, retired in June after more than two decades as the president of Shubert and more than 60 years in the New York theater world.
He said the coronavirus crisis, which shuttered the Theater District in March, created a natural time for him to step down from his perch at the company, which operates 17 Broadway theaters. Robert Wankel succeeded him as Shubert’s chair.
Preventing Wnt from hitching a ride may offer new avenue for novel treatments for cancer and fibrosis.
Wnt in complex with its transporter WLS. Wnt (green) modified by an attached lipid (red) is transported by the carrier protein Wntless (shades of light brown) from its site of synthesis to the plasma membrane. The attached lipid is buried deep in the Wntless structure.
David M. Virshup
SINGAPORE, 12 January 2021 – Researchers from Duke-NUS Medical School in Singapore and Columbia University in the US have solved how Wnt proteins, which play a fundamental role in cell proliferation and differentiation, hitch a ride to travel from their cellular factory to the cell surface. Drugs that interfere with Wnt transport, like the made-in-Singapore anti-cancer drug ETC-159, can be used to treat diseases with excess Wnt signalling, such as cancer and fibrosis.