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Scientists seek to block pathogen’s most reliable weapon to cause severe malaria The parasites that cause severe malaria are well-known for the sinister ways they infect humans, but new research may lead to drugs that could block one of their most reliable weapons: interference with the immune response. In the study, scientists defined the atomic-level architecture of the connection between a protein on the surface of a parasite-infected red blood cell when it binds to a receptor on the surface of an immune cell. When that protein-receptor connection is made under normal circumstances, the infected red blood cell, hijacked by the disease-causing parasite, de-activates the immune cell - meaning the body won t fight the infection. A drug designed to fit into that space could block the interaction, allowing the immune system to get to work clearing away the pathogen.

Kai xuEmily hendersonOhio state universityNational institutes of healthNational institutesAssistant professorVeterinary biosciencesகை ஐயூஎமிலி ஹென்டர்சன்ஓஹியோ நிலை பல்கலைக்கழகம்தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம்தேசிய நிறுவனங்கள்உதவியாளர் ப்ரொஃபெஸர்கால்நடை உயிர் அறிவியல்