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Store Fat or Burn It? Targeting a Single Protein Flips the Switch As obesity becomes a growing issue worldwide – nearly tripling over the last-half century – scientists are trying to gain a better understanding of the condition at the molecular level. Now, new research led by UC San Francisco scientists suggests that a single protein could play an outsized role in weight gain. As reported in  Nature Metabolism on Feb. 18, 2021, UCSF’s Davide Ruggero, PhD, and colleagues found that mice in which activity of a protein called eIF4E is diminished, either genetically or pharmaceutically, gain only half the weight of other mice, even if all the mice eat a high-fat diet.

United statesYasuo oguriDavide ruggeroAlmal burlingameAlma burlingameKenji ikedaHarrisonj tomRyanm gillHieu vuShingo kajimuraSupna nairChaojun yangRalphj deberardinisCancer researchEffector therapeutics incUt southwestern medical center