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 E-Mail IMAGE: Human enzyme METTL3 adds methyl groups to introduce m6A in SARS-CoV-2 s RNA. That modification prevents the virus RNA from triggering inflammatory molecules known as cytokines. METTL3 also leads to increased. view more  Credit: UC San Diego Health Sciences Researchers at University of California San Diego School of Medicine have discovered one way in which SARS-CoV-2, the coronavirus that causes COVID-19, hijacks human cell machinery to blunt the immune response, allowing it to establish infection, replicate and cause disease. In short, the virus genome gets tagged with a special marker by a human enzyme that tells the immune system to stand down, while at the same time ramping up production of the surface proteins that SARS-CoV-2 uses as a doorknob to enter cells.

United statesSan diegoUniversity of california san diegoMark zellerKristiang andersonDavey smithTariq ranaBill brayGwendolyn michelle gonzalezAaronf carlinRob knightYinsheng wangScripps researchDivision of geneticsDepartment of pediatricsMoores cancer center