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Researchers identify six words used by specific immune cells to call up immune defense genes

Researchers identify six “words” used by specific immune cells to call up immune defense genes UCLA life scientists have identified six words that specific immune cells use to call up immune defense genes an important step toward understanding the language the body uses to marshal responses to threats. In addition, they discovered that the incorrect use of two of these words can activate the wrong genes, resulting in the autoimmune disease known as Sjögren s syndrome. The research, conducted in mice, is published this week in the peer-reviewed journal Immunity (Cell Press). Cells have evolved an immune response code, or language. We have identified some words in that language, and we know these words are important because of what happens when they are misused. Now we need to understand the meaning of the words, and we are making rapid progress. It s as exciting as when archaeologists discovered the Rosetta stone and could begin to read Egyptian hieroglyphs.

Researchers Decode the Language of Immune Cells

  In this image from a microscopy video, scientists listen to macrophages as they responded to an immune threat. Credit: Brooks Taylor/ UCLA Life Sciences Read Time: UCLA life scientists have identified six words that specific immune cells use to call up immune defense genes an important step toward understanding the language the body uses to marshal responses to threats. In addition, they discovered that the incorrect use of two of these words can activate the wrong genes, resulting in the autoimmune disease known as Sjögren s syndrome. The research, conducted in mice, is published this week in the peer-reviewed journal Immunity (Cell Press).

Scientists decode the language of immune cells -- Science & Technology -- Sott net

© Brooks Taylor/UCLA In this image from a microscopy video, scientists “listen” to macrophages as they responded to an immune threat. UCLA life scientists have identified six words that specific immune cells use to call up immune defense genes an important step toward understanding the language the body uses to marshal responses to threats. In addition, they discovered that the incorrect use of two of these words can activate the wrong genes, resulting in the autoimmune disease known as Sjögren s syndrome. The research, conducted in mice, is published this week in the peer-reviewed journal Immunity ( Cell Press). Cells have evolved an immune response code, or language, said senior author Alexander Hoffmann, the Thomas M. Asher Professor of Microbiology and director of the Institute for Quantitative and Computational Biosciences at UCLA. We have identified some words in that language, and we know these words are important because of what happens when they are misuse

Scientists decode language of immune cells

Brooks Taylor/UCLA Life Sciences In this image from a microscopy video, scientists “listen” to macrophages as they responded to an immune threat. UCLA life scientists have identified six “words” that specific immune cells use to call up immune defense genes an important step toward understanding the language the body uses to marshal responses to threats. In addition, they discovered that the incorrect use of two of these words can activate the wrong genes, resulting in the autoimmune disease known as Sjögren’s syndrome. The research, conducted in mice, is published this week in the peer-reviewed journal Immunity (Cell Press).

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