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Common anti-depressant may be first-ever treatment for osteoarthritis
Researchers found that Paroxetine not only slows down cartilage degeneration, but also promotes cartilage health in both mice and human cartilage in vitro.
Image: Fadia Kamal, Penn State
Common anti-depressant may be first-ever treatment for osteoarthritis
Sara LaJeunesse
February 10, 2021
HERSHEY, Pa. A disease of the joints, osteoarthritis affects more than 30 million adults and is the fifth-leading cause of disability in the United States. In a new study, scientists have discovered the cellular pathway that leads to osteoarthritis and have identified a commonly used anti-depressant paroxetine that inhibits this pathway.
The team found that Paroxetine not only slows down cartilage degeneration, but also promotes cartilage health in both mice and human cartilage in vitro. The drug may be the first-ever treatment for this debilitating, degenerative disease.
Mar. 2—There's no dashboard. No speedometer, odometer or oil-pressure gauge. You won't find dials or buttons to control the heat, air conditioning, windshield wipers or defrosters. It's as quiet as a mouse and can go from zero to 60 mph in 3.2 seconds with a top speed of 162 mph. It's the 2021 Model 3 Tesla, and Berea Police Department's newest police cruiser. On Monday, the Berea Police .
Credit Elaine Cromie / Bridge Michigan
For much of last year, Michigan’s nurses and other frontline workers were sometimes called names, cursed at, or lied to.
They scrambled to fill staff shortages, track down masks or other supplies, and, in some cases, as the virus tore through their communities, found there was precious little they could do for thousands of the sick and dying.
Then, finally, vaccines arrived.
And nearly one year after the virus was first confirmed in Michigan, these same health workers are finding their days filled with an entirely different emotion:
Joy.
It arrives in less than a milliliter, appointment after appointment, syringe after syringe.
After nearly a year of frustration and death, frontline healthcare workers are finding gratitude in being able to say “congratulations” as they deliver vaccines to eager residents.