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$2 3M boost puts Hawaiʻi gene therapy research on the map | University of Hawaiʻi System News

UC Davis. The $2.3 million grant is significant because it was a first-time submission and received a score in the 1st percentile, higher than 99% of grants submitted from institutions across all 50 states in the U.S. “Directed evolution of a sequence-specific targeting technology for therapeutic gene delivery to the human genome,” Owens’ grant addresses drawbacks to current genome editing technologies that randomly insert a therapeutic gene, which can disrupt important host genes and potentially cause cancer. Methods like CRISPR (clustered regularly interspaced short palindromic repeats), a family of DNA sequences in genomes of organisms, are inefficient in non-dividing cells and delivering large

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