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Despite a daunting more than 130 million cases of SARS-CoV-2 infections to date worldwide, another global pathogen - the Aedes mosquito-borne dengue virus - saw a record number of over 400 million cases in 2019. But vaccine development has been challenging due to the need to protect equally against all four dengue strains. The discovery of new possible biomarkers to predict clinical and immune responses to dengue virus infection, published today in
Nature Communication, could be critical to informing future vaccines.
As with SARS-CoV-2 infection, the effects of dengue virus infection can range from asymptomatic to severe disease that can be fatal. Climate change has expanded the viruses geographic distribution far beyond tropical areas like Southeast Asia and Latin America to the southern U.S. and Europe. Only one vaccine, Dengvaxia, has been approved for a subset of at-risk individuals in endemic areas.
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Northwestern researchers developed a computing device to associate light with pressure, according to a University release. The device operates like a human brain.
The study was published on April 30 in scientific journal Nature Communication and was conducted in collaboration with the University of Hong Kong. The National Science Foundation, the Hong Kong General Research Fund and the National Natural Science Foundation of China funded the project.
The modern computer, while very capable, cannot measure up to the human brain’s ability to execute complex tasks like pattern recognition and motor control, co-author and McCormick Prof. Jonathan Rivnay said in the release. The plasticity of the brain’s synapses are key to these abilities, he added.
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The scientific community is focusing its research into the multiple applications of Hydrogels, polymeric materials which contains a large amount of water, that have the potential to reproduce the features of biological tissues. This aspect is particularly significant in the field of regenerative medicine, which since a long time has already recognised and been using the characteristics of these materials. In order to be used effectively to replace organic tissues, hydrogels must meet two essential requirements: possessing great geometric complexity and, after suffering of a damage, being able to self-heal independently, exactly like living tissues.
The development of these materials may now be easier, and cheaper, thanks to the use of 3D printing: the researchers in the MP4MNT (Materials and Processing for Micro and Nanotechnologies) team of the Department of Applied Science and Technology of the Politecnico di Torino, coordinated by Professor Fabrizio Pirri, have demonst
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