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NIH Mourns the Passing of George Harold Patterson
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Credit: NASA
Scientists have long thought that there was a direct connection between the rise in atmospheric oxygen, which started with the Great Oxygenation Event 2.5 billion years ago, and the rise of large, complex multicellular organisms.
That theory, the Oxygen Control Hypothesis, suggests that the size of these early multicellular organisms was limited by the depth to which oxygen could diffuse into their bodies. The hypothesis makes a simple prediction that has been highly influential within both evolutionary biology and geosciences: Greater atmospheric oxygen should always increase the size to which multicellular organisms can grow.
It s a hypothesis that s proven difficult to test in a lab. Yet a team of Georgia Tech researchers found a way using directed evolution, synthetic biology, and mathematical modeling all brought to bear on a simple multicellular lifeform called a snowflake yeast . The results? Significant new information on the correlations between oxyg
4 faculty named inaugural Hubbard-Walder honorees
4 faculty named inaugural Hubbard-Walder honorees
By: Jack Rossi | 2021.04.28 | 09:24 am
Four University of Iowa faculty members Gail Bishop, Ray Fagenbaum, Cinda Coggins-Mosher, and Amy Strathman were named winners of the inaugural Hubbard-Walder Award for Excellence in Teaching.
The new award is presented to UI faculty who have participated in a variety of university teaching (undergraduate, graduate or professional, classroom, one-on-one) and have contributed to curriculum and/or program development. Each recipient has a minimum six years of teaching experience at Iowa and will receive a $1,000 honorarium.
Gail Bishop Bishop is the Roy J. and Lucille A. Carver College of Medicine Distinguished Professor of Microbiology and Holden Chair of Cancer Biology as well as the associate director for basic science research in the Holden Comprehensive Cancer Center. In her 32-year tenure, Bishop’s high-quality teaching
Biologists unravel pathway for cancer cells to become immortal
By: Richard C. Lewis | 2021.03.03 | 11:07 am
Cancer cells have been described as immortal because, unlike normal cells, they don’t age and die, but instead can continue to multiply without end.
In most cases, cancer cells become immortal by invoking a genetic mutation that can trigger the production of an enzyme, known as telomerase, which prevents telomeres from shortening. Telomeres are important because they prevent DNA-containing chromosomes from damage or fusing with nearby chromosomes. The longer the telomere, the better protected the chromosome and the DNA within it.
But there is another, less understood way how cancer cells achieve immortality. In a new study, University of Iowa biologist Anna Malkova explored Alternative Lengthening of Telomeres (ALT), a second pathway that cancer cells employ to maintain telomeres. Malkova and Josep Comeron, professor of biology at Iowa, analyzed baker’s ye
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