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The researchers screened more than 20 different probiotic species for their ability to tighten the TJ barrier. They tested the bacteria in cultures of a human cell line called Caco-2, which scientists often use to model the intestinal epithelium. Only LA1 caused a rapid, strong tightening of the TJ barrier. The bacteria appeared to achieve this by activating a protein in the membrane of the cells, called a Toll-like receptor. Toll-like receptors, part of the body’s immune defenses, recognize patterns on the surface of microbes. Similar to ringing an intruder alarm, when the bacterium bound to the receptors, it triggered a train of events inside the cells that tightened the TJ barrier.

United statesAndrew brookes gettyThomas maCenters for diseasePenn state college of medicineHershey medical centerDisease controlPenn state collegeAmerican journalNews todayஒன்றுபட்டது மாநிலங்களில்ஆண்ட்ரூ ப்ரூக்ஸ் கெட்டிதாமஸ் மாமையங்கள் க்கு நோய்பென் நிலை கல்லூரி ஆஃப் மருந்துஹெர்ஷே மருத்துவ மையம்