Gene Editing Hold Potential to Correct Retinal Degenerations by Angela Mohan on January 20, 2021 at 11:44 AM
Gene editing therapies, including CRISPR-Cas systems hold promise in correcting mutations that are responsible for inherited retinal degenerations.
Technological advances in gene editing, continuing safety concerns, and strategies to overcome these challenges are highlighted in the peer-reviewed journal
Human Gene Therapy. Currently, the field is undergoing rapid development with a number of competing gene editing strategies, including allele-specific knock-down, base editing, prime editing, and RNA editing, are under investigation. Each offers a different balance of on-target editing efficiency versus off-target risks, state Kanmin Xue, University of Oxford, and coauthors.