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IMAGE: Bernese mountain dogs present a high incidence of familial cancers: histiocytic sarcoma (in black), lymphoma (in blue), and mast cell tumor (in green). This breed represents a unique model to. view more
Credit: Hédan B et al., 2021, PLOS Genetics
Six genetic variants add up to determine the risk of several blood cancers in pre-disposed dog breeds, according to a study by Benoît Hédan at the University of Rennes and colleagues, publishing April 8th in the open-access journal
PLOS Genetics. The results confirm a known tumour-suppressor gene as a risk factor for histiocytic sarcoma a rare and aggressive blood cancer that affects both dogs and humans as well as identifying four new genetic loci associated with the disease.