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CAR T Cells Target CDH17 Antigen, Suppress GI Tumor Cells, Overlook Healthy Cells

A new study finds immunotherapy with CAR T cells suppresses neuroendocrine tumors and gastrointestinal cancers, without toxicity to healthy tissue.

Zijie fengXianxin huaAbramson family cancer research institute at pennPenn medicineNature cancerAbramson family cancer research institute

Penn-Developed CAR T Cells Suppress GI Solid Tumor Cells, Without Toxicity to Healthy Tissue, in Preclinical Research

Chimeric antigen receptor (CAR) T cells can be remarkably effective in treating leukemias and lymphomas, but there are no successful immunotherapies for neuroen

University of pennsylvaniaUnited statesDavidc metzZijie fengTerencep gadeBryson katonaXianxin huaAbramson family cancer research institute at pennGastrointestinal cancer genetics programCare for carcinoid foundation research grantNational institutes of healthPerelman school of medicineUniversity of pennsylvania health systemDepartment of cancer biologyNeuroendocrine tumor research foundationRuth perelman school of medicine

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