The findings could pave the way toward new treatments for Alzheimer’s disease (AD).
“By treating AD mouse models with a compound to inhibit these enzymes, we were able to normalize gene expression, restore neuronal function, and ameliorate cognitive impairment,” says senior author Zhen Yan, a professor in the department of physiology and biophysics in the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo.
Alzheimer’s disease alters the expression of genes in the prefrontal cortex, a key region of the brain controlling cognitive processes and executive functions.
When they focused on gene changes caused by epigenetic processes (those not related to changes in DNA sequences) such as aging, the researchers could reverse elevated levels of harmful genes that cause memory deficits in AD.
Exercise Important To Battle ARDS Caused By COVID-Even During Winter
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Exercise May Reduce Your Risk of This COVID-19 Complication
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IMAGE: Zhen Yan, PhD, and his collaborators aim to identify the sources, functions and targets of the molecules that provide exercise s well-documented health benefits. view more
Credit: Dan Addison | UVA Communications
A top exercise researcher and colleagues at the University of Virginia School of Medicine have launched an ambitious effort to understand the whole-body benefits of exercise so that doctors can use that information to prevent and treat disease.
Zhen Yan, PhD, and his collaborators aim to identify the sources, functions and targets of the molecules that provide exercise s well-documented health benefits. By understanding this, doctors will better understand how exercise helps fend off disease, and they may be able to design drugs to mimic those benefits for people who cannot exercise, such as those with limited mobility. The cutting-edge research could open new doors both for preventing and treating many common illnesses, the researchers hope.
Exercise May Reduce Your Risk of This COVID-19 Complication
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