“With the current electoral map, Perikatan Nasional or PAS couldn’t win the state (in the 2023 state election). I have huge reservations about their ability to win with the addition of new (mixed) seats”
(FMT) - An analyst has questioned the odds of PAS taking over Selangor in the next general ele
UMNO president flexes muscles, drops PM s loyalists from electoral line-up — BenarNews benarnews.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from benarnews.org Daily Mail and Mail on Sunday newspapers.
打造 太仓速度 科教创新区样板_苏州都市网 szdushi.com.cn - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from szdushi.com.cn Daily Mail and Mail on Sunday newspapers.
Overexpression of PGC1 in vascular smooth muscle cells ameliorates atherosclerosis
In a new study published in
Circulation Research, Chen-Yu Zhang and Xiaohong Jiang s group from Nanjing University and Dongjin Wang s group from Nanjing Drum Tower Hospital reported a critical role of PGC1α in maintaining the contractile phenotype of vascular smooth muscle cells (VSMCs) and highlighted the therapeutic potential of PGC1α for atherosclerosis.
The traditional view holds that aberrant proliferation of VSMCs promotes plaque formation after vessel injury and inflammation, whereas the presence of VSMCs in the fibrous cap of the plaque is beneficial.
Although it has long been assumed that these seemingly contradictory functions of VSMCs during atherosclerosis arise from their remarkable plasticity, direct evidence that VSMCs undergo phenotypic switching during atherogenesis in vivo has only been proven recently by rigorous lineage tracing studies.