Chris Mugalu, who scored from the spot when the two teams met in the group s first game, headed over the bar after he received a cross from Miquissone.
Shomari Kapombe did well to find some space before he placed the ball onto Miquissone s path and the Mozambican was able to produce a cross high enough for Mugalu to head home in the 15th minute.
Another chance for Simba came in the 17th minute when Miquisonne and Mugalu found themselves inside AS Vita s area but the former s effort hit the side net.
Miquissone, who scored a brilliant goal against Al Ahly that was later voted as the goal of the week, tried a similar trick in the 21st minute but Ousmane Ouattara read him well and stole the ball as the forward was about to pull the trigger.
Ahly salvage last-gasp draw, Kaizer Chiefs win with nine men
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Simba SC vs AS Vita Club: TV channel, live stream, team news and preview
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CAF Champions League wrap
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Sundowns, Wydad, Esperance reach last eight, Ahly set to join them Johannesburg (AFP) – Mamelodi Sundowns, Wydad Casablanca and Esperance on Tuesday became the first qualifiers for the CAF Champions League quarter-finals, and title-holders Al Ahly are set to join them.
Sundowns of South Africa are the only club boasting a perfect record after matchday 4 as Lebohang Maboe scored on 28 minutes in a 1-0 Group B win over TP Mazembe from the Democratic Republic of Congo in Pretoria.
Wydad of Morocco dropped points for the first time in Group C after a 0-0 draw at second-place Horoya of Guinea in Conakry, but the stalemate did not prevent them securing a sixth consecutive last-eight place.