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Chimeric Antigen Receptor T (CAR-T) cellular therapies allow a patientâs T cells to be genetically modified to display receptors for tumor cell proteins, leading to binding and destruction. This therapy has come a long way since its inception in the late 1980s by immunologist Zelig Eshhar at the Weizmann Institute of Science in Israel. In 2017 the first CAR-T therapies, focused on B cell malignancies, were approved by the U.S. Food and Drug Administration (FDA). These therapies have changed the treatment landscape for hematologic malignancies, but suffer from several significant shortcomings:
CAR-T therapies can induce cytokine release syndrome (CRS), a potentially fatal and rapid release of cytokines
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PHILADELPHIA: International cancer cell therapy pioneer Carl June, MD, the Richard W. Vague Professor in Immunotherapy in the department of Pathology and Laboratory Medicine in the Perelman School of Medicine at the University of Pennsylvania and director of the Center for Cellular Immunotherapies at Penn’s Abramson Cancer Center, has been named a 2021 Dan David Prize Laureate.
The Dan David Prize is endowed by the Dan David Foundation, headquartered at Tel Aviv University, which annually awards three prizes of $1 million each to globally inspiring individuals and organizations, honoring outstanding contributions that expand knowledge of the past, enrich society in the present, and promise to improve the future of the world.