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Neutrophil PAD4: How does it function in cancer beyond promoting NETosis?

Neutrophil PAD4: How does it function in cancer beyond promoting NETosis?
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Laura garcia geriqueYulia nefedovaChui dengWistar instituteCancer researchNovel selective inhibitorMediated neutrophil migrationSuppress tumor progression

The Wistar Institute: Wistar Scientists Discover Innate Tumor Suppression Mechanism

Findings could benefit African Americans who possess a specific genetic variant of p53PHILADELPHIA, PA, May 04, 2023, a journal of the American Association for Cancer Research, researchers at The Wistar

United statesUniversity of pennsylvaniaFox chase cancer centerNew yorkWistar institutehaveIsabela batista olivaYulia nefedovaToshitha kannanJessicac leungCenterand ira brindSvena millerPeter vogelDavidy luJoel casselNicolea kirvenJohn karanicolas

Wistar Scientists Discover Innate Tumor Suppression Mechanism

Wistar Scientists Discover Innate Tumor Suppression Mechanism
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University of pennsylvaniaUnited statesFox chase cancer centerNew yorkNoam auslanderIsabela batista olivaDavidy luThibaut barnoudDaniel claiborneToshitha kannanSvena millerChunlei shaoNicole clarkeJoel casselKevinp battaileJamesf dougherty

Jubilant Therapeutics Announces Research Collaboration with The Wistar Institute to Evaluate the Activity of Novel PAD4 Inhibitors to Reduce Clinical Severity of COVID-19

(1) BEDMINSTER, N.J., Jan. 15, 2021 /PRNewswire/ Jubilant Therapeutics Inc., a biopharmaceutical company advancing small molecule modulators to address unmet medical needs in oncology and autoimmune diseases, today announced a collaboration with The Wistar Institute, an international leader in biomedical research, to evaluate the ability of Peptidyl Arginine Deiminase 4 (PAD4) inhibitors provided by Jubilant Therapeutics to block neutrophil extracellular trap (NET) formation in the context of COVID-19 related cytokine storms. PAD4 is an enzyme that catalyzes conversion of arginine to citrulline in proteins, including histones and is highly expressed in neutrophils. Histone citrullination has been implicated in Neutrophil Extracellular Trap (NET) formation and accumulating evidence suggests that NETs may be linked to the severity of COVID-19, as their formation is a result of pro-inflammatory cytokine release syndrome (CRS), or cytokine storms, produced by the body s immune resp

United statesKostenloser wertpapierhandelSyed kazmiYulia nefedovaNational cancer instituteCancer centerJubilant therapeutics incJubilant life sciencesPrnewswire jubilant therapeutics incWistar instituteMicroenvironment metastasis programTherapeutics incPeptidyl arginineJubilant therapeuticsNeutrophil extracellular trapChief executive officer