The brain s flexibility and ability to cope with loss of neurons or other lesions in the brain is called cognitive reserve. In a 15-year follow-up study, researchers at the division of Aging Research Center (ARC), Karolinska Institutet, suggest that lifelong cognitive reserve helps maintain late-life cognitive health by delaying cognitive transition in the preclinical stages of dementia. The results of their findings were recently published in Alzheimers & Dementia.