Post-pandemic resilience in the Pacific region presents some unique, context-specific, economic, social, environmental, and political challenges as well as opportunities. This study aims at developing a holistic definition of post-pandemic resilience in the Pacific context, based on the interconnected aspects and factors that contribute. As there is a gap in the literature for a holistic definition of post-pandemic resilience based on empirical studies from the Pacific Island countries, this study tries to plug that gap. Using a qualitative systems thinking approach, data was collected from primary and secondary sources including semi-structured interviews with ten senior leaders in the Pacific. This study first captures the multiple levels and different interconnected aspects of post-pandemic resilience in the Pacific and then presents a holistic definition. An analysis of the different papers published in this special issue based on this holistic definition and their contexts is also