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Research reveals how mitochondria keep their reactive oxygen species production in check Mitochondria, the powerhouse of the cell, convert sustenance into energy, fueling the cell s activities. In addition to power, mitochondria also produce reactive oxygen species, byproduct molecules primed to help facilitate communication among the other units in the cells. But when produced too abundantly, they damage DNA and render some cellular components dysfunctional. Now, an international research team has revealed how mitochondria keep their reactive oxygen species production in check. They published their results on June 30 in Frontiers in Cell and Developmental Biology. Excessive generation of reactive oxygen species in mitochondria damages mitochondria and reduces cell function, so the mechanism by which mitochondria maintain production of reactive oxygen species is crucial for cells. In this study, we found that mitochondria have a mechanism to spontaneously avoid the production of

Yoshihiro ohtaYoushiki suganumaTakahiro shibataSawako kimuraYusho kuraokaEmily hendersonTakumi onojimaJannatul aklimaYoshiki oieLife science at tokyo university of agricultureLuca science incDepartment of biochemistry molecular biologyTechnology agencyDepartment of biotechnologyResearch instituteProgram on open innovation platform