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Combination may be new standard in EGFR -mutant non-small cell lung cancer

Combination may be new standard in EGFR -mutant non-small cell lung cancer
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South koreaByoung chul choLazertinib leclazaOsimertinib tagrissoAmivantamab rybrevantZosia piotrowskaBymark leiserYonsei cancer center

Rybrevant-Leclaza Combo Outperforms Tagrisso in EGFR-Mutant Advanced NSCLC

Patients with advanced non-small cell lung cancer with an EGFR mutation had a greater risk reduction for disease progression with frontline Rybrevant plus Leclaza compared with Tagrisso alone.

Soult ukpyolsiSouth koreaByoung chul choYonsei cancer centerLung cancerEsmo 2023

Dr Cho on First-Line Amivantamab Plus Lazertinib in EGFR-Mutant NSCLC

Byoung Chul Cho, MD, PhD, discusses key findings from the phase 3 MARIPOSA study of first-line amivantamab plus lazertinib vs osimertinib in EGFR-mutant locally advanced or metastatic non– small cell lung cancer.

Soult ukpyolsiSouth koreaByoung chul choDivision of medical oncologyYonsei university college of medicineYonsei cancer centerMedical oncologyYonsei university college

Landmark Phase 3 MARIPOSA Study Shows

Early data show an overall survival trend favoring the combination of amivantamab and lazertinib compared to osimertinib; consistent results seen in.

South koreaUnited statesSoult ukpyolsiRegion flamandeRepublic of koreaJannsen cilag gmbJanssen cilag gmbByoung chul choEuropean society for medical oncologyAmerican lung associationEuropean unionJanssen research developmentYuhan corporationJanssen biotech incYonsei university college of medicineNational cancer institute

Amivantamab Plus Lazertinib Improved PFS for EGFR-Mutated Advanced NSCLC

MARIPOSA demonstrated the combination reduced risk of progression or death by 30% compared with osimertinib. MARIPOSA-2 found amivantamab plus chemotherapy and amivantamab plus chemotherapy and lazertinib also improved progression-free survival (PFS) over chemotherapy after progression on osimertinib.

United statesSoult ukpyolsiSouth koreaRepublic of koreaAntonio passaroByoung chul choZofia piotrowskaYonsei university college of medicineHarvard medical schoolEuropean institute of oncologyYonsei cancer centerDivision of thoracic oncologyHarvard medical school zofia piotrowskaYonsei university collegeThoracic oncologyEuropean institute

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