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A path to aggressive breast cancer
Researchers at Baylor College of Medicine have followed the progression of breast cancer in an animal model and discovered a path that transforms a slow-growing type of cancer known as estrogen receptor (ER)+/HER2+ into a fast-growing ER-/HER2+ type that spreads or metastasizes to other organs.
The study, which appears in the Proceedings of the National Academy of Sciences, has implications for breast cancer therapy as it suggests the need to differentiate cancer subtypes according to the path the cells follow. Different paths might be linked to different cancer behavior, which should be taken into consideration to plan treatment appropriately.