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Catching burglar
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Comment les mutations du Covid-19 changent la donne de la pandémie
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Neuropilin 1 is a receptor protein found on the surface of many cells that triggers the transportation of the molecules that bind to it inside the cell. It also allows molecules to be passed from cell to cell. In 3D tissue, that means something binding toneuropilin 1 on the top layer of cells could easily reach the middle layers of cells.
Some people in cancer biology are very interested in it for this reason. If you can trigger neuropilin 1, you can increase the uptake of small drug molecules into otherwise solid tumours.
How does this help the virus?
This is still a hypothesis, but we think viruses able to trigger neuropilin 1 might be able to dig deeper into tissues without first having to replicate themselves in the upper layer of cells. That would be an amazing bypassing mechanism for a virus.