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High ammonia levels lead to fewer T cells and immunotherapy resistance in colorectal cancer

High levels of ammonia in tumors lead to fewer T cells and immunotherapy resistance in mouse models of colorectal cancer, new findings from the University of Michigan Rogel Cancer Center revealed.

Horacew davenportYatrik shahHannah bellEmily hendersonUniversity of michigan rogel cancer centerMichigan rogel cancer centerIndustry focusCollegiate professorCell metabolismColorectal cancer

High levels of ammonia in colon cancer restrict T cell development: Research

The researchers discovered, ammonia inhibits the growth and function of T cells, which are essential for anti-tumour immunity.

Horacew davenportYatrik shahHannah bellUniversity of michigan rogel cancer centerMichigan rogel cancer centerCollegiate professorHannah bellYatrik shahHoracew davenport

Researchers reveal how ammonia dysregulates T cell function

Researchers reveal how ammonia dysregulates T cell function
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Horacew davenportYatrik shahHannah bellUniversity of michigan rogel cancer centerMichigan rogel cancer centerCollegiate professor

Tumor Ammonia Levels Inhibit T Cell Growth, Impact Immunotherapy

Tumor Ammonia Levels Inhibit T Cell Growth, Impact Immunotherapy
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