Hard to drug: Protein droplets reveal new ways to inhibit transcription factors in an aggressive form of prostate cancer
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Targeting the Androgen Receptor More Effectively in Prostate Cancer
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<ul> <li>Many of the most potent human oncoproteins belong to a class of proteins called transcription factors, but designing small molecule drugs that target transcription factors is a major challenge.</li> <li>An international team of researchers from the Institute for Research in Biomedicine (IRB Barcelona), the Max Planck Institute for Molecular Genetics (MPIMG), BC Cancer (University of British Columbia) and other institutions has discovered a potential way to target the androgen receptor, the most prominent oncogenic transcription factor in prostate cancer, based on its propensity to form droplets also known as condensates.</li> <li>The results described in this publication set the basis for the foundation of Nuage Therapeutics, a spinoff of IRB Barcelona and ICREA.</li> <li>The findings are published in <em>Nature Structural & Molecular Biology</em>.</li>
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A change in rigidity switches the function of protein condensates involved in sensing touch
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