This week marks the third African Medicines Regulatory Harmonization (AMRH) week a critical touch point in ongoing efforts to expand access to quality-assured medicines across the African continent. However, a big concern looms: how to best ensure long-term sustainable funding for regulatory systems to protect recent gains and make further progress. This blog describes a few levers to make the case for regulatory systems strengthening, and outlines three key recommendations to secure sustainable financing and build on the current momentum.