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Unmasking the Protein Accomplice in COVID-19 Spread

Unmasking the Protein Accomplice in COVID-19 Spread
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New insight into how the occludin protein mediates cell-to-cell transmission of SARS-CoV-2 virus

While the coronavirus continues to infect people around the world, researchers at the University of Missouri have identified a specific protein inside the human body that plays a critical role in how the virus spreads from cell to cell after infection -; a discovery that will help better understand the COVID-19 disease and could lead to the development of new antiviral drugs in the future.

Occludin protein plays key role in spread of

While the coronavirus continues to infect people around the world, researchers at the University of Missouri have identified a specific protein inside the human body that plays a critical role in how the virus spreads from cell to cell after infection a discovery that will help better understand the COVID-19 disease and could lead to the development of new antiviral drugs in the future. The finding provides new insight into how the protein, known as the occludin protein, serves as a mediator for cell-to-cell transmission of the virus.

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Price: Scientists atSt. JudeChildren’s Research Hospital are working with colleagues in China to develop better therapy for childhood acute lymphoblastic leukemia (ALL). Results from a large phase 3 noninferiority clinical trial definitively showed that vincristine and dexamethasone pulses can be eliminated in patients with low-risk disease. The findings were published today in The Lancet Oncology. Adding the chemotherapy vincristine plus a steroid (originally prednisone, and later dexamethasone) as pulse therapy for childhood ALL has been part of standard care since the 1970s. This is despite their being associated with neuropsychological side effects, neuropathy and other late effects. However, to date studies about the need for prolonged treatment with pulse therapy have been inconclusive.

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