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Among patients with disabling strokes without medium or large occlusions, more of those taking tirofiban had good function at 90 days than those on aspirin, results of the RESCUE BT2 trial show.
(UPDATED) For patients with acute ischemic strokes caused by large-vessel occlusions, forgoing IV thrombolytics before mechanical thrombectomy may be a viable option, according to the results of two trials published online this week in
JAMA.
In the DEVT trial, taking patients directly to the cath lab resulted in noninferior 90-day functional outcomes compared with the guideline-recommended approach of administering IV alteplase before the intervention, lead author Wenjie Zi, MD (Xinqiao Hospital and The Second Affiliated Hospital, Chongqing, China), and colleagues report.
And in the SKIP trial, which was initially presented at the International Stroke Conference last year, functional outcomes were similar with the two strategies. The trial, however, did not establish the noninferiority of skipping IV thrombolytics, a result attributed to higher-than-expected rates of recanalization and favorable outcomes.