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Novel brain organoid model unveils link between inflammation and astrocyte dysfunction

Discovery: Faulty DNA Disposal System Linked to Inflammation

Cells in the human body contain power-generating mitochondria, each with their own mtDNA a unique set of genetic instructions entirely separate from the cell’s nuclear DNA that mitochondria use to create life-giving energy. When mtDNA remains where i

Faulty DNA disposal system causes inflammatio

<p>Salk scientists discovered a pathway from mitochondrial DNA replication stress to immune system activation and inflammation, finding that endosomes responsible for disposing of dysfunctional mitochondrial DNA were leaking&nbsp;mitochondrial DNA into the cell and prompting the inflammatory immune response. The pathway provides new targets for therapeutics that disrupt inflammation during aging and disease.</p>

Inflammation Linked to Faulty DNA Disposal System

Inflammation Linked to Faulty DNA Disposal System
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