Inhalable COVID-19 vaccine? Rice University scientists developing vaccine spray in fight against coronavirus
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In this rendition, a phage particle displays a region of the SARS-CoV-2 spike protein that retains a near-native structural conformation. Administration of this phage in mice induces a systemic immune response against the spike protein. This versatile technology serves as a first step towards developing cost-effective and easy-to-manufacture vaccines for COVID-19 and other infectious agents. (Christopher Markosian/Daniela Staquicini/Rutgers Cancer Institute of New Jersey/Rutgers New Jersey Medical School)
HOUSTON – Scientists at Rice University’s Center for Theoretical Biological Physics announced they are a part of the development of an inhalable COVID-19 vaccination.
PhageNova Bio, Inc Announces Publication of Design and Development of Experimental COVID-19 Vaccines
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PhageNova Bio, Inc Announces Publication of Design and Development of Experimental COVID-19 Vaccines
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Scientists develop new inhalation delivery system for vaccines
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Last Updated: Dec 11, 2020, 05:16 PM IST
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Synopsis
The findings, published in the journal Med, suggests that a safe and effective lung delivery system could be developed for vaccines and therapeutics against pathogens such as the novel coronavirus.
Reuters
The researchers next plan to examine the kinetics of pulmonary transport after multiple doses and investigate cell-based immune responses.
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Scientists have developed an
inhalation
delivery
system
for
vaccines which generates potent immune responses in mice and non-human primates, without causing lung damage, an advance which may lead to
new therapeutics
for respiratory diseases like COVID-19.
Researchers find new method for safe and effective delivery of medicines to the lungs
Investigators at Rutgers Cancer Institute of New Jersey and Rutgers New Jersey Medical School recently identified a new method for safe and effective delivery of medicines to the lungs that can be used for multiple clinical applications, potentially including aerosol vaccination. The results of the study will be published online ahead of print in the December issue of
Med (10.1016/j.medj.2020.10.005).
Targeted pulmonary delivery may have many conceptual advantages over other routes of vaccine administration and therapeutics, particularly for certain respiratory infections (including but not limited to SARS-CoV-2) because they arrive directly at the site of the infection.