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 E-Mail Scientists have for the first time revealed the structure surrounding important receptors in the brain s hippocampus, the seat of memory and learning. The study, carried out at Oregon Health & Science University, published today in the journal Nature. The new study focuses on the organization and function of glutamate receptors, a type of neurotransmitter receptor involved in sensing signals between nerve cells in the hippocampus region of the brain. The study reveals the molecular structure of three major complexes of glutamate receptors in the hippocampus. The findings may be immediately useful in drug development for conditions such as epilepsy, said senior author Eric Gouaux, Ph.D., senior scientist in the OHSU Vollum Institute, Jennifer and Bernard Lacroute Endowed Chair in Neuroscience Research and an Investigator with the Howard Hughes Medical Institute.

United statesJie yuSarah clarkEric gouauxJohns hopkinsJaba mitraPrashant raoJohns hopkins universityPacific northwest centerOregon health science universityNeuroscience researchVollum instituteHoward hughes medical instituteNational institute of neurological disordersOregon healthScience university