Doxorubicin may upregulate MALAT-1 in osteosarcoma
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Photothermal and therapeutic efficiency of indocyanine green
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7,8 and organ protection from ischemia/reperfusion injury.
9,10 Newly synthesized transition metal carbonyl-compounds, CO release molecules (CORMs), are effective in regulating CO release in vivo and in vitro in appropriate circumstances.
11 These CO releasing molecules can therefore be used as the new carrier to provide exogenous CO. CORM-3 [tricarbonylchloro (glycinato) ruthenium (II)] is completely soluble in water with fast release of CO when dissolved in a physiological solution.
By releasing CO, CORMs also induce an anti-inflammatory effect. Our previous study showed that CORM-2 reduced periodontal inflammation and alveolar bone resorption in rats with experimental periodontitis.
13 We also reported CORM-3 suppressed the expression of adhesion molecules in human gingival fibroblasts co-stimulated by tumor necrosis factor-α and interleukin-1 β,
1
1Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, People’s Republic of China;
2Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, People’s Republic of China
Correspondence: Yang Tang; Xianglin Yuan
Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, Hubei Province, China
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Background and Purpose: Brain metastasis is among the leading causes of death in patients with non-small-cell lung cancer (NSCLC). Through yet unknown mechanisms, prophylactic cranial irradiation (PCI) can significantly decrease the incidence of brain metastases. Given that PCI probably exerts indirect anti-tumoral effects by turning cerebral “soil” unfavorable for the colonization of metastatic tumor “seeds”. This study