doctors believe biden is suffering a rare case of rebound positivity experienced by some coronavirus patients. earlier i asked dr peter hotez, co director of the texas children s hospital center for vaccine development how a covid rebound infection comes about. well, what happens is, you know, you take a course of paxlovid, which you typically give early on in the course of the illness in order to stop virus replication. after a five day course that should be the end of it, particularly if you are also vaccinated in addition to getting the medicine. but in the clinical trials for paxlovid it was shown about 1 2% of individuals several days later actually had a rebound infection, and it was considered a rare event. but those studies were done with pre 0micron virus lineages. now, with the 0micron sub variants, it may not be so rare. we don t have the exact number, they are a bit all over the place, some people
infection comes about. what happens is, you know, you take a course of paxlovid, which you typically give early on in the course of the illness in order to stop virus replication. after a five day course that should be the end of it, particularly if you are also vaccinated in addition to getting the medicine. but in the clinical trials for paxlovid it was shown about i 2% of individuals several days later actually had a rebound infection, and it was considered a rare event. but those studies were done with pre omicron virus lineages. now, with the omicron sub variants, it may not be so rare. we don t have the exact number, they are a bit all over the place, some people are saying 20%, 30%. i don t think we really know. it happened to me personally after going on paxlovid. it happened to my good colleague dr tony fauci, it happened to the president. anecdotally it appears to be more common than we were led to understand from the clinical trials, and it may be because of these unique omi
minutes. what it is you re going to be watching for, of course, as we hear about the president s condition, his condition progress and now, of course, his treatment of paxlovid. yeah, i think there s both a good news story and a concerning news story. the good news story, he is being maxed out on interventions, as everyone has been reporting he s been vaccinated and doubly boosted. he s on paxlovid which works in the early phase of inhibiting virus replication, the concerning news is his age and we know that as good as two boosts are which it is the best we can do, the centers for disease control reported last week that two dose, two boosts are about 80% protective against hospitalization and 66% protective against emergency room visits and that s just a week or so after getting the boost and we know that that protection declines subsequently, so i think we have to be very cautious and that even though he is doubly boosted
response we re always going to be lagging, chasinging and hoping our immunity would outpace these variants? it doesn t have to be that way, laura, and the reason we say that, that is true. when you have a lot of dynamics of a virus replication in the community, you give a virus more of an opportunity to mutate. more likely, you ll get a new variant. by diminishing the circulation of virus in the community by vaccinations and boosting and masking where appropriate, and testing so that you can keep people separated who are infected, you cut down on that likelihood that you re going to get new variants, and with regard to the vaccines, it s important that you try and not only get a booster, but as you get more variants, we re going to be upgrading and updating the next level of boosters so that
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