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Only Two Interchangeable Ways to Fold Genomes into Nuclei

Scientists have mapped 3D genome organization at a chromosomal level in 24 eukaryotic species, including animals, fungi, and plants, and concluded there are only two basic ways in which genomes are packaged into the nuclei of cells. The authors show that these two states of nuclear architecture can be switched in evolution, or in the lab, by mutating a protein called condensin II, a protein known to play a role in cell division.

Biologists construct a periodic table for cell nuclei

 E-Mail HOUSTON - (May 27, 2021) - One hundred fifty years ago, Dmitri Mendeleev created the periodic table, a system for classifying atoms based on the properties of their nuclei. This week, a team of biologists studying the tree of life has unveiled a new classification system for cell nuclei and discovered a method for transmuting one type of cell nucleus into another. The study, which appears this week in the journal Science, emerged from several once-separate efforts. One of these centered on the DNA Zoo, an international consortium spanning dozens of institutions including Baylor College of Medicine, the National Science Foundation-supported Center for Theoretical Biological Physics (CTBP) at Rice University, the University of Western Australia and SeaWorld.

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