After the recess, Ramalepe intercepted a loose ball before firing from the edge of the box to break the deadlock in the 64th minute before Darya Stezhko doubled the lead one minute later.
Minsk were further reduced to nine players when Natalia Asmykovich was sent off in the 75th minute as Anastasia Linnik extended Dinamo to a three-goal lead a minute later.
Four minutes from full-time, Stezhko bagged her second of the match and the fourth to wrap the big triumph at the Minsk Stadium.
South Africa s Ramalepe was in action for the duration, along with Ivorian Cisse, while Mulaudzi featured in the final six minutes and Cameroon s Dabda saw 84 minutes of the contest for Dinamo.