However, after 14 minutes, Ramadan Sobhi equalised for Pyramid after intense pressure on the defence of Enyimba.
Although the first half ended 1-1, on resumption, the coach Fatai Osho tutored side ran out of steam and allowed their hosts to take full control of proceedings.
It therefore became a one way traffic situation as the Pyramids boys did all the scoring as Enyimba struggled to save what was left of their reputation.
Abdallah Said scored Pyramids’ second goal four minutes into the second half before Ibrahim Adel’s brace in the 58th and 67th minute completed the rout of Enyimba.
The return leg of the quarter-final tie comes up on Sunday, May 23 in Aba.