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Tuesday, December 22, 2020
How genes get ‘switched on’ has fascinated scientists for decades, but equally important questions about how they are ‘turned off’ have been largely overlooked.
As the messengers carrying instructions from DNA for the creation of proteins, the formation and decay of cellular RNAs is critical to maintaining cell stability and regulation – and of direct bearing on how our immune systems respond to disease.
Researchers at the Yale Chemical Biology Institute have begun to untangle the complex pathways used by RNAs and the biological processes that they regulate.
Published today in the journal Cell Chemical Biology, the scientists reveal a new biological tool to help pinpoint numerous specific RNA “depletion” pathways and associated protein complexes.