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In trans women receiving hormone therapy, body fat and insulin resistance increases, with opposite effects in trans men. These metabolic alterations may affect the risk of developing type 2 diabetes in trans women and trans men.
It is known that hormone therapy leads to changes in insulin resistance with an increase in insulin resistance with feminizing hormone therapy, whereas reverse is true for masculinizing hormone therapy. Van Velzen and colleagues aimed to clarify whether this change in insulin resistance leads to an effect on the incidence of type 2 diabetes in patients on hormone therapy.