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Gift boosts efforts to understand and combat rare cancers

Gift boosts efforts to understand and combat rare cancers Apr 9 2021 Curing cancer has been the dream of countless doctors and researchers over the decades. Yet some types of cancer, whether because they affect relatively few people or lack influential advocates, receive less attention and funding than others. Cells from a rare cancer known as blastic plasmacytoid dendritic cell neoplasm, shown in purple and blue, appear among red blood cells. Image: Clin Med Insights Case Rep 2013. doi: 10.4137/CCRep.S12608, CC-BY-NC 3.0 A recent gift to Harvard Medical School is boosting efforts to understand and combat these understudied malignancies. Established at HMS in 2019 by the Switzerland-based Bertarelli Foundation, the Bertarelli Rare Cancers Fund provides $15 million in support of research projects and community building around rare cancers.

Gift supports research into rare cancers, community-building

Gift supports research into rare cancers, community-building
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Study offers insight into metabolic pathways hijacked by SARS-CoV-2 for viral replication

SARS-CoV-2 hijacks two key metabolic pathways to rapidly replicate in host cells

 E-Mail When SARS-CoV-2, the virus that causes COVID-19, infects a human cell, it quickly begins to replicate by seizing the cell s existing metabolic machinery. The infected cells churn out thousands of viral genomes and proteins while halting the production of their own resources. Researchers from Brigham and Women s Hospital, Massachusetts General Hospital (MGH), and the Broad Institute, studying cultured cells shortly after infecting them with the virus, now have more insight into the metabolic pathways co-opted by the virus. The findings, published in Nature Communications, highlight the potential therapeutic benefit of drugs such as methotrexate, which inhibit folate and one-carbon metabolic pathways appropriated by the virus.

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