Grapevine leaf extract inhibits SARS-CoV-2 and HSV-1 replication in the lab
Researchers in Italy have shown that leaf extract from the common grapevine –
Vitis vinifera – exhibits significant antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).
“Wines and winery bioproducts, such as grape pomace, skins, and seeds, are rich in bioactive compounds against a wide range of human pathogens, including bacteria, fungi, and viruses,” says Carla Zannella from the University of Campania and colleagues.
“However, little is known about the biological properties of vine leaves,” they add.
Now, the team has evaluated the phenolic composition and antiviral activity of
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Sale a subasta una pintura de Lavinia Fontana hallada en una colección española
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Researchers at Cornell, Columbia University Irving Medical Center and Erasmus Medical Center in the Netherlands have developed a nasal formulation that blocks the spread of COVID-19 among ferrets â and are hopeful the formulation could have the same effect on humans, and potentially generate therapeutic treatments as well.
Ferrets are one of the best animal models for COVID-19, because they take the virus quite readily, and undergo both direct contact and airborne transmission. Ferrets, similar to humans, also generate antibodies against the virus, yet display limited clinical signs.
âThis is a simple nasal formulation that we think can prevent the transmission of SARS-CoV-2 in humans,â said Chris Alabi, associate professor of chemical and biomolecular engineering and a co-senior author of the paper. âThe beauty of the research is its simplicity. The ultimate goal is to create a nasal spray drug product that can be made widely available, one that can be kept