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Discovery of severe form of mpox spurs call for update to list of AIDS-defining diseases

Analyses of cases in earlier outbreaks of mpox, the viral disease formerly known as monkeypox, and of a small number of patients infected in the current multi-country outbreak suggested that people with advanced HIV may suffer more severe infections.

Viral dynamics in patients with monkeypox infection: a prospective cohort study in Spain

In immunocompetent patients with mild monkeypox disease, PCR data alone would suggest a contact isolation period of 3 to 6 weeks but, based on detection of replication-competent virus, this time could be reduced. Based on findings from this cohort of patients, semen testing and prolonged use of condoms after recovery from monkeypox might not be necessary.

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