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Alain Braillon and Adam Edward Lang raise important questions about e-cigarettes and harm reduction in response to our Comment.1 Here, we explain why a pragmatic approach to maximising e-cigarettes’ harm reduction potential is important.

City ofUnited kingdomNew zealandNorth yorkshireUnited statesWake forest universityFrench cancer instituteMental healthElsevier ltdUnited kingdom research forumUs national institutes of healthYorkshire cancer researchInternational tobacco control policy evaluationCentre for addictionUniversity of malayaLondon smoking cessation transformation programme