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Surprising New Role Discovered for Major Immune Regulator

Surprising New Role Discovered for Major Immune Regulator
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United statesUnited kingdomBingxu liuPaul blaineyDarrell irvineNir hacohenBroad instituteKoch instituteHarvard medical schoolKoch institute for integrative cancer researchRagon instituteDrug administrationDivision of health sciencesMassachusetts general hospitalUnderwood prescott professorBiological engineering

Study finds a surprising new role for a major immune regulator: In addition to turning on genes involved in cell defense, the STING protein also acts as an ion channel, allowing it to control a wide variety of immune responses

Study finds a surprising new role for a major immune regulator: In addition to turning on genes involved in cell defense, the STING protein also acts as an ion channel, allowing it to control a wide variety of immune responses
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United statesPaul blaineyDarrell irvineNir hacohenBingxu liuCancer research institute bristol myers squibb fellowshipUs national institutes of healthJohn hertz foundation fellowshipDivision of health sciencesBroad instituteHoward hughes medical instituteDrug administrationRagon instituteKoch institute for integrative cancer researchHarvard medical schoolKoch institute

Study finds a surprising new role for a major immune regulator

The immune regulatory protein STING has a previously unknown function: acting as an ion channel that allows protons to leak into cells. This discovery makes it the first human immune sensor that can translate danger signals into ion flow.

United statesBingxu liuNir hacohenDarrell irvinePaul blaineyUs national institutes of healthCancer research institute bristol myers squibb fellowshipJohn hertz foundation fellowshipDivision of health sciencesBroad instituteHoward hughes medical instituteRagon instituteDrug administrationKoch institute for integrative cancer researchHarvard medical schoolEuropean molecular biology organization fellowship

Environmental News Network - Vaccine delivers a boost to T cell therapy

Environmental News Network - Vaccine delivers a boost to T cell therapy
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United statesDarrell irvineGerd altmannKoch institute for integrative cancer researchMassachusetts instituteRagon instituteUnderwood prescott professorBiological engineeringMaterials scienceIntegrative cancer research

Vaccine boosts response of engineered T cells, may help eradicate solid tumors

Vaccine boosts response of engineered T cells, may help eradicate solid tumors
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Darrell irvineLeyuan maDrug administrationUniversity of pennsylvania school medicineKoch instituteKoch institute for integrative cancer researchRagon instituteUnderwood prescott professorBiological engineeringMaterials scienceIntegrative cancer researchPennsylvania schoolElicio therapeutics