Understanding Kratom and Its Alkaloids Kratom leaves contain various alkaloids, including mitragynine and 7-hydroxymitragynine, which interact with receptors in the body and produce physiological effects. Kratom has a long history of traditional use in Southeast Asian cultures for its potential therapeutic properties, such as pain relief, mood enhancement, increased energy, and relaxation. Pain Relief and Kratom One of the most well-known benefits of kratom is its potential as a natural pain reliever. Kratom's pain-relieving properties can be attributed to its