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Hormones in brain may explain how exercise improves metabolism
A collaboration between the USC Leonard Davis School of Gerontology and researchers in South Korea has shown how moderate exercise prompts cells in the hypothalamus, the small region within the brain that controls metabolism, to release a hormone called MOTS-c. MOTS-c is a small protein that is encoded in cells’ smaller mitochondrial genome, rather than the larger collection of genes in the nucleus, said Changhan David Lee, assistant professor of gerontology at the USC Leonard Davis School and co-senior author of the new study.
Mitochondria, while more commonly known as the energy-producing parts of cells, have in recent years been found to play much bigger roles in health and aging by providing instructions for cellular processes. Subsequent studies by Lee and his colleagues have shown how mitochondrial-encoded MOTS-c interacts with the nuclear genome and regulates cellular metabolism and stress responses.
Credit: Stephanie Kleinman/USC
A mitochondrial hormone expressed by cells deep in the brain appears to play a role in improving metabolism and fighting off obesity, according to a new study in mice.
A collaboration between the USC Leonard Davis School of Gerontology and researchers in South Korea has shown how moderate exercise prompts cells in the hypothalamus, the small region within the brain that controls metabolism, to release a hormone called MOTS-c. MOTS-c is a small protein that is encoded in cells smaller mitochondrial genome, rather than the larger collection of genes in the nucleus, said Changhan David Lee, assistant professor of gerontology at the USC Leonard Davis School and co-senior author of the new study.
Credit: POSTECH
The honor of the 2020 Nobel Prize in Chemistry went to those who developed lithium-ion rechargeable batteries. These batteries have become an essential energy source for electronic devices ranging from small IT devices to electric vehicles. Tesla, a leading U.S. automaker, recently emphasized the need to establish an innovative production system and reduce battery cost. The price of batteries accounts for a large portion of electric vehicles and cost reduction is vital to popularizing them.
A joint research team, led by Professor Soojin Park and Ph.D. candidate Hye Bin Son of POSTECH s Department of Chemistry with Professor Seungmin Yoo of Ulsan College, has successfully developed a multi-functional separator which allows the batteries to function even when the pouch cell is assembled in ambient air. These findings were introduced in the latest online edition of
Presented at: TCT 2019. September 27, 2019.
Unplanned PCI following TAVI is rare, but when necessary, interventionalists are almost always able to successfully revascularize the occluded artery, according to data from an international registry. The incidence of unplanned PCI is highest in the first week after TAVI, declining over time, and the most common reason for the procedure in the first 2 years after valve implantation is acute coronary syndrome, particularly NSTEMI, according to researchers.
Interestingly, the type of valve implanted had no impact on PCI outcomes, with operators reporting similar rates of successful revascularization in those treated with balloon-expandable and self-expanding bioprostheses. The self-expanding Evolut (Medtronic) valve, with its taller frame, is thought by some to make coronary reaccess more difficult when compared with other valve types.
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